Ophiuchus Queen will often launch multiple snakes in succession down all three columns. Rapidly move from side to side, utilize the shield, or attack the snakes with the Rock Buster's charged shot to prevent taking any damage from the snakes.

Ophiuchus Queen will stand on one of the two side columns and rush down that column as well as the middle column at the same time. This technique is unblockable. Ophiuchus Queen will rush to your row before returning to her side of the battlefield. Move to the opposite side of the field the moment you see two columns light up.

Ophiuchus Queen will stop and focus energy in her eyes as the column she rests on will light up. She will then fire an unblockable beam attack down the column. Move to the side to avoid this attack. This technique can stun.